MicroRNAs are endogenous, noncoding, small RNAs that regulate expression and function
of genes, but little is known about regulation of microRNA in the kidneys under normal or
pathologic states. Here, we generated a mouse model in which the proximal tubular cells
lack Dicer, a key enzyme for microRNA production. These mice had normal renal function
and histology under control conditions despite a global downregulation of microRNAs in the
renal cortex; however, these animals were remarkably resistant to renal ischemia …