Identity by descent between distant relatives: detection and applications
SR Browning, BL Browning - Annual review of genetics, 2012 - annualreviews.org
Annual review of genetics, 2012•annualreviews.org
Short segments of identity by descent (IBD) between individuals with no known relationship
can be detected using genome-wide single nucleotide polymorphism data and recently
developed statistical methodology. Emerging applications for the detected IBD segments
include IBD mapping, haplotype phase inference, genotype imputation, and inference of
population structure. In this review, we explain the principles behind methods for IBD
segment detection, describe recently developed methods, discuss approaches to comparing …
can be detected using genome-wide single nucleotide polymorphism data and recently
developed statistical methodology. Emerging applications for the detected IBD segments
include IBD mapping, haplotype phase inference, genotype imputation, and inference of
population structure. In this review, we explain the principles behind methods for IBD
segment detection, describe recently developed methods, discuss approaches to comparing …
Short segments of identity by descent (IBD) between individuals with no known relationship can be detected using genome-wide single nucleotide polymorphism data and recently developed statistical methodology. Emerging applications for the detected IBD segments include IBD mapping, haplotype phase inference, genotype imputation, and inference of population structure. In this review, we explain the principles behind methods for IBD segment detection, describe recently developed methods, discuss approaches to comparing methods, and give an overview of applications.
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