[HTML][HTML] Multiple roles for NaV1. 9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease–derived stimuli
JRF Hockley, G Boundouki, V Cibert-Goton, C McGuire… - PAIN®, 2014 - Elsevier
Chronic visceral pain affects millions of individuals worldwide and remains poorly
understood, with current therapeutic options constrained by gastrointestinal adverse effects.
Visceral pain is strongly associated with inflammation and distension of the gut. Here we
report that the voltage-gated sodium channel subtype Na V 1.9 is expressed in half of gut-
projecting rodent dorsal root ganglia sensory neurons. We show that Na V 1.9 is required for
normal mechanosensation, for direct excitation and for sensitization of mouse colonic …
understood, with current therapeutic options constrained by gastrointestinal adverse effects.
Visceral pain is strongly associated with inflammation and distension of the gut. Here we
report that the voltage-gated sodium channel subtype Na V 1.9 is expressed in half of gut-
projecting rodent dorsal root ganglia sensory neurons. We show that Na V 1.9 is required for
normal mechanosensation, for direct excitation and for sensitization of mouse colonic …