Interferon-β enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune …
B Schreiner, M Mitsdoerffer, BC Kieseier, L Chen… - Journal of …, 2004 - Elsevier
Antigen-presenting cells (APC) are considered to play a critical role in promoting the (re)
activation of potentially autoreactive T cells in multiple sclerosis (MS), an inflammatory
demyelinating disorder of the central nervous system (CNS). B7-H1 (PD-L1) is a novel
member of the B7 family proteins which exert costimulatory and immune regulatory
functions. Here we characterize the expression and functional activity of B7-H1 expressed
on monocytes and dendritic cells (DC) of healthy donors and MS patients. B7-H1 is …
activation of potentially autoreactive T cells in multiple sclerosis (MS), an inflammatory
demyelinating disorder of the central nervous system (CNS). B7-H1 (PD-L1) is a novel
member of the B7 family proteins which exert costimulatory and immune regulatory
functions. Here we characterize the expression and functional activity of B7-H1 expressed
on monocytes and dendritic cells (DC) of healthy donors and MS patients. B7-H1 is …