[HTML][HTML] Mucosal mast cells are pivotal elements in inflammatory bowel disease that connect the dots: stress, intestinal hyperpermeability and inflammation
A Farhadi, JZ Fields, A Keshavarzian - World journal of …, 2007 - ncbi.nlm.nih.gov
A Farhadi, JZ Fields, A Keshavarzian
World journal of gastroenterology: WJG, 2007•ncbi.nlm.nih.govMast cells (MC) are pivotal elements in several physiological and immunological functions of
the gastro-intestinal (GI) tract. MC translate the stress signals that has been transmitted
through brain gut axis into release of proinflammatory mediators that can cause stimulation
of nerve endings that could affect afferent nerve terminals and change their perception,
affect intestinal motility, increase intestinal hyperpermeability and, in susceptible individuals,
modulate the inflammation. Thus, it is not surprising that MC are an important element in the …
the gastro-intestinal (GI) tract. MC translate the stress signals that has been transmitted
through brain gut axis into release of proinflammatory mediators that can cause stimulation
of nerve endings that could affect afferent nerve terminals and change their perception,
affect intestinal motility, increase intestinal hyperpermeability and, in susceptible individuals,
modulate the inflammation. Thus, it is not surprising that MC are an important element in the …
Abstract
Mast cells (MC) are pivotal elements in several physiological and immunological functions of the gastro-intestinal (GI) tract. MC translate the stress signals that has been transmitted through brain gut axis into release of proinflammatory mediators that can cause stimulation of nerve endings that could affect afferent nerve terminals and change their perception, affect intestinal motility, increase intestinal hyperpermeability and, in susceptible individuals, modulate the inflammation. Thus, it is not surprising that MC are an important element in the pathogenesis of inflammatory bowel disease and non inflammatory GI disorders such as IBS and mast cell enterocolitis.
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