The concept of bacterial translocation and gut-origin sepsis as a cause of systemic infectious
complications and the multiple organ dysfunction syndrome (MODS) in surgical and ICU
patients has emerged over the last several decades, although the exact clinical relevance of
these phenomena continues to be debated. Thus, the goal of this review is to trace the
evolution of gut-origin sepsis and gut-induced MODS and put these disorders and
observations into clinical perspective. Additionally, the mechanisms leading to gut-derived …