[HTML][HTML] Tryptophanyl-tRNA synthetase mediates high-affinity tryptophan uptake into human cells
M Miyanokoshi, T Yokosawa, K Wakasugi - Journal of Biological Chemistry, 2018 - ASBMB
The tryptophan (Trp) transport system has a high affinity and selectivity toward Trp, and has
been reported to exist in both human and mouse macrophages. Although this system is
highly expressed in interferon-γ (IFN-γ)–treated cells and indoleamine 2, 3-dioxygenase 1
(IDO1)–expressing cells, its identity remains incompletely understood. Tryptophanyl-tRNA
synthetase (TrpRS) is also highly expressed in IFN-γ–treated cells and also has high affinity
and selectivity for Trp. Here, we investigated the effects of human TrpRS expression on Trp …
been reported to exist in both human and mouse macrophages. Although this system is
highly expressed in interferon-γ (IFN-γ)–treated cells and indoleamine 2, 3-dioxygenase 1
(IDO1)–expressing cells, its identity remains incompletely understood. Tryptophanyl-tRNA
synthetase (TrpRS) is also highly expressed in IFN-γ–treated cells and also has high affinity
and selectivity for Trp. Here, we investigated the effects of human TrpRS expression on Trp …