Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR.

JE Park, HH Chen, J Winer, KA Houck… - Journal of Biological …, 1994 - ASBMB
The recently identified placenta growth factor (PIGF) is a member of the vascular endothelial
growth factor (VEGF) family of growth factors. PIGF displays a 53% identity with the platelet-
derived growth factor-like region of VEGF. By alternative splicing of RNA, two PIGF isoforms
are generated: PIGF131 (PIGF-1) and PIGF152 (PIGF-2). Relative to PIGF131, PIGF152 has
a 21-amino acid insertion enriched in basic amino acids. Little is known at the present time
about the significance and function of these proteins. To assess their potential role, we …