Neonatal antigen-presenting cells are functionally more quiescent in children born under traditional compared with modern environmental conditions
JG Lisciandro, SL Prescott, MG Nadal-Sims… - Journal of allergy and …, 2012 - Elsevier
BACKGROUND: One explanation for the high burden of allergic and autoimmune diseases
in industrialized countries is inappropriate immune development under modern
environmental conditions. There is increasing evidence that the process of immune
deviation already begins in utero, but the underlying immunologic mechanisms are not
clear. OBJECTIVE: We sought to identify differences in the function of neonatal antigen-
presenting cells (APCs) in children born in settings that are more traditional versus those of …
in industrialized countries is inappropriate immune development under modern
environmental conditions. There is increasing evidence that the process of immune
deviation already begins in utero, but the underlying immunologic mechanisms are not
clear. OBJECTIVE: We sought to identify differences in the function of neonatal antigen-
presenting cells (APCs) in children born in settings that are more traditional versus those of …