The induction of donor-specific tolerance to transplanted cells and organs, while preserving
immune function as a whole, remains a highly sought after and elusive strategy for
overcoming transplant rejection. Tolerance necessitates modulating a diverse array of cell
types that recognize and respond to alloantigens, including antigen presenting cells and T
lymphocytes. Nanotherapeutic strategies that employ cellular and biomaterial engineering
represent an emerging technology geared towards the goal of inducing transplant tolerance …