[HTML][HTML] Antioxidant-induced nuclear translocation of CCAAT/enhancer-binding protein β: a critical role for protein kinase a-mediated phosphorylation of Ser299
R Chinery, JA Brockman, DT Dransfield… - Journal of Biological …, 1997 - ASBMB
Alterations in intracellular oxidative status activate several signal transduction pathways
resulting in distinct patterns of gene expression. Treatment of colorectal cancer cells with
antioxidants can lead to apoptosis by induction of p21 through a mechanism involving
CCAAT/enhancer-binding protein β (C/EBPβ). Herein, we demonstrate that the antioxidant
pyrrolidinedithiocarbamate activates cAMP-dependent protein kinase (PKA) in a colorectal
cancer cell line DKO-1. Activation of PKA phosphorylates Ser 299 within C/EBPβ, which is …
resulting in distinct patterns of gene expression. Treatment of colorectal cancer cells with
antioxidants can lead to apoptosis by induction of p21 through a mechanism involving
CCAAT/enhancer-binding protein β (C/EBPβ). Herein, we demonstrate that the antioxidant
pyrrolidinedithiocarbamate activates cAMP-dependent protein kinase (PKA) in a colorectal
cancer cell line DKO-1. Activation of PKA phosphorylates Ser 299 within C/EBPβ, which is …