[HTML][HTML] Sequential phosphorylation mediates receptor-and kinase-induced inhibition of TREK-1 background potassium channels
J Murbartián, Q Lei, JJ Sando, DA Bayliss - Journal of Biological Chemistry, 2005 - ASBMB
Background potassium channels determine membrane potential and input resistance and
serve as prominent effectors for modulatory regulation of cellular excitability. TREK-1 is a
two-pore domain background K+ channel (KCNK2, K2P2. 1) that is sensitive to a variety of
physicochemical and humoral factors. In this work, we used a recombinant expression
system to show that activation of Gα q-coupled receptors leads to inhibition of TREK-1
channels via protein kinase C (PKC), and we identified a critical phosphorylation site in a …
serve as prominent effectors for modulatory regulation of cellular excitability. TREK-1 is a
two-pore domain background K+ channel (KCNK2, K2P2. 1) that is sensitive to a variety of
physicochemical and humoral factors. In this work, we used a recombinant expression
system to show that activation of Gα q-coupled receptors leads to inhibition of TREK-1
channels via protein kinase C (PKC), and we identified a critical phosphorylation site in a …