Development of immune organs and functioning in humans and test animals: Implications for immune intervention studies
CF Kuper, J van Bilsen, H Cnossen, G Houben… - Reproductive …, 2016 - Elsevier
A healthy immune status is mostly determined during early life stages and many immune-
related diseases may find their origin in utero and the first years of life. Therefore, immune
health optimization may be most effective during early life. This review is an inventory of
immune organ maturation events in relation to developmental timeframes in minipig, rat,
mouse and human. It is concluded that time windows of immune organ development in
rodents can be translated to human, but minipig reflects the human timeframes better; …
related diseases may find their origin in utero and the first years of life. Therefore, immune
health optimization may be most effective during early life. This review is an inventory of
immune organ maturation events in relation to developmental timeframes in minipig, rat,
mouse and human. It is concluded that time windows of immune organ development in
rodents can be translated to human, but minipig reflects the human timeframes better; …