[HTML][HTML] Epithelial mesenchymal transition induces aberrant glycosylation through hexosamine biosynthetic pathway activation
MC Lucena, P Carvalho-Cruz, JL Donadio… - Journal of Biological …, 2016 - ASBMB
Deregulated cellular metabolism is a hallmark of tumors. Cancer cells increase glucose and
glutamine flux to provide energy needs and macromolecular synthesis demands. Several
studies have been focused on the importance of glycolysis and pentose phosphate pathway.
However, a neglected but very important branch of glucose metabolism is the hexosamine
biosynthesis pathway (HBP). The HBP is a branch of the glucose metabolic pathway that
consumes∼ 2–5% of the total glucose, generating UDP-GlcNAc as the end product. UDP …
glutamine flux to provide energy needs and macromolecular synthesis demands. Several
studies have been focused on the importance of glycolysis and pentose phosphate pathway.
However, a neglected but very important branch of glucose metabolism is the hexosamine
biosynthesis pathway (HBP). The HBP is a branch of the glucose metabolic pathway that
consumes∼ 2–5% of the total glucose, generating UDP-GlcNAc as the end product. UDP …