Attenuation of murine lupus nephritis by mycophenolate mofetil.
MC Van Bruggen, B Walgreen, TP Rijke… - Journal of the …, 1998 - journals.lww.com
Mycophenolate mofetil (MMF) is the morpholinoethyl ester of mycophenolic acid, which is its
active metabolite. MMF is effective in prolonging survival of allografts and xenografts.
However, little is known about the effects and the main mechanism of action of MMF in
autoimmune diseases. In this study, the effect of MMF on the spontaneous disease
progression in the MRL/lpr mouse model of lupus was examined. Eight-week-old MRL/lpr
mice (n= 18) were orally treated with MMF dissolved in a vehicle (90 mg/kg) once a day …
active metabolite. MMF is effective in prolonging survival of allografts and xenografts.
However, little is known about the effects and the main mechanism of action of MMF in
autoimmune diseases. In this study, the effect of MMF on the spontaneous disease
progression in the MRL/lpr mouse model of lupus was examined. Eight-week-old MRL/lpr
mice (n= 18) were orally treated with MMF dissolved in a vehicle (90 mg/kg) once a day …