[HTML][HTML] Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4 …
PA Grimsrud, MJ Picklo, TJ Griffin… - Molecular & cellular …, 2007 - ASBMB
Obesity is a state of mild inflammation correlated with increased oxidative stress. In general,
pro-oxidative conditions lead to production of reactive aldehydes such as trans-4-hydroxy-2-
nonenal (4-HNE) and trans-4-oxo-2-nonenal implicated in the development of a variety of
metabolic diseases. To investigate protein modification by 4-HNE as a consequence of
obesity and its potential relationship to the development of insulin resistance, proteomics
technologies were utilized to identify aldehyde-modified proteins in adipose tissue. Adipose …
pro-oxidative conditions lead to production of reactive aldehydes such as trans-4-hydroxy-2-
nonenal (4-HNE) and trans-4-oxo-2-nonenal implicated in the development of a variety of
metabolic diseases. To investigate protein modification by 4-HNE as a consequence of
obesity and its potential relationship to the development of insulin resistance, proteomics
technologies were utilized to identify aldehyde-modified proteins in adipose tissue. Adipose …