Objective Carnosine has been shown to modulate triglyceride and glycation levels in cell
and animal systems. In this study we investigated whether prolonged supplementation with
carnosine inhibits atherosclerosis and markers of lesion stability in hyperglycaemic and
hyperlipidaemic mice. Methods Streptozotocin-induced diabetic apo E−/− mice were
maintained for 20 weeks, post-induction of diabetes. Half of the animals received carnosine
(2 g/L) in their drinking water. Diabetes was confirmed by significant increases in blood …