[HTML][HTML] The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4
T Imai, M Baba, M Nishimura, M Kakizaki… - Journal of Biological …, 1997 - ASBMB
Thymus and activation-regulated chemokine (TARC) is a recently identified CC chemokine
that is expressed constitutively in thymus and transiently in stimulated peripheral blood
mononuclear cells. TARC functions as a selective chemoattractant for T cells that express a
class of receptors binding TARC with high affinity and specificity. To identify the receptor for
TARC, we produced TARC as a fusion protein with secreted alkaline phosphatase (SEAP)
and used it for specific binding. By stably transfecting five orphan receptors and five known …
that is expressed constitutively in thymus and transiently in stimulated peripheral blood
mononuclear cells. TARC functions as a selective chemoattractant for T cells that express a
class of receptors binding TARC with high affinity and specificity. To identify the receptor for
TARC, we produced TARC as a fusion protein with secreted alkaline phosphatase (SEAP)
and used it for specific binding. By stably transfecting five orphan receptors and five known …