[HTML][HTML] The chemokine CXCL14 (BRAK) stimulates activated NK cell migration: implications for the downregulation of CXCL14 in malignancy
T Starnes, KK Rasila, MJ Robertson, Z Brahmi… - Experimental …, 2006 - Elsevier
OBJECTIVE: The primary function of chemokines is the regulation of leukocyte trafficking by
stimulating directional chemotaxis. The chemokine CXCL14 (BRAK) is highly expressed in
all normal tissues, but is not expressed in most malignant tissues. The chemotactic activity of
CXCL14 has been difficult to characterize. Recently it was reported that CXCL14 is a
chemoattractant for activated monocytes and immature dendritic cells. Given that CXCL14 is
downregulated upon transition to malignancy, we sought to characterize whether CXCL14 …
stimulating directional chemotaxis. The chemokine CXCL14 (BRAK) is highly expressed in
all normal tissues, but is not expressed in most malignant tissues. The chemotactic activity of
CXCL14 has been difficult to characterize. Recently it was reported that CXCL14 is a
chemoattractant for activated monocytes and immature dendritic cells. Given that CXCL14 is
downregulated upon transition to malignancy, we sought to characterize whether CXCL14 …