[HTML][HTML] The Neddylation-Cullin 2-RBX1 E3 Ligase Axis Targets Tumor Suppressor RhoB for Degradation in Liver Cancer*[S]
J Xu, L Li, G Yu, W Ying, Q Gao, W Zhang, X Li… - Molecular & cellular …, 2015 - ASBMB
The neddylation-cullin-RING E3 ligase (CRL) pathway has recently been identified as a
potential oncogenic event and attractive anticancer target; however, its underlying
mechanisms have not been well elucidated. In this study, RhoB, a well known tumor
suppressor, was identified and validated with an iTRAQ-based quantitative proteomic
approach as a new target of this pathway in liver cancer cells. Specifically, cullin 2-RBX1 E3
ligase, which requires NEDD8 conjugation for its activation, interacted with RhoB and …
potential oncogenic event and attractive anticancer target; however, its underlying
mechanisms have not been well elucidated. In this study, RhoB, a well known tumor
suppressor, was identified and validated with an iTRAQ-based quantitative proteomic
approach as a new target of this pathway in liver cancer cells. Specifically, cullin 2-RBX1 E3
ligase, which requires NEDD8 conjugation for its activation, interacted with RhoB and …