The ubiquitin receptor Rad23: at the crossroads of nucleotide excision repair and proteasomal degradation

NP Dantuma, C Heinen, D Hoogstraten - DNA repair, 2009 - Elsevier
A protein that exemplifies the intimate link between the ubiquitin/proteasome system (UPS)
and DNA repair is the yeast nucleotide excision repair (NER) protein Rad23 and its human
orthologs hHR23A and hHR23B. Rad23, which was originally identified as an important
factor involved in the recognition of DNA lesions, also plays a central role in targeting
ubiquitylated proteins for proteasomal degradation, an activity that it shares with other
ubiquitin receptors like Dsk2 and Ddi1. Although the finding that Rad23 serves as a ubiquitin …