[HTML][HTML] CD36 binds oxidized low density lipoprotein (LDL) in a mechanism dependent upon fatty acid binding
AG Jay, AN Chen, MA Paz, JP Hung… - Journal of Biological …, 2015 - ASBMB
The association of unesterified fatty acid (FA) with the scavenger receptor CD36 has been
actively researched, with focuses on FA and oxidized low density lipoprotein (oxLDL)
uptake. CD36 has been shown to bind FA, but this interaction has been poorly characterized
to date. To gain new insights into the physiological relevance of binding of FA to CD36, we
characterized FA binding to the ectodomain of CD36 by the biophysical method surface
plasmon resonance. Five structurally distinct FAs (saturated, monounsaturated (cis and …
actively researched, with focuses on FA and oxidized low density lipoprotein (oxLDL)
uptake. CD36 has been shown to bind FA, but this interaction has been poorly characterized
to date. To gain new insights into the physiological relevance of binding of FA to CD36, we
characterized FA binding to the ectodomain of CD36 by the biophysical method surface
plasmon resonance. Five structurally distinct FAs (saturated, monounsaturated (cis and …