Nitric oxide's reactions with hemoglobin: a view through the SNO-storm
MT Gladwin, JR Lancaster Jr, BA Freeman… - Nature medicine, 2003 - nature.com
MT Gladwin, JR Lancaster Jr, BA Freeman, AN Schechter
Nature medicine, 2003•nature.comS-nitroso-hemoglobin (SNOHb) has been proposed to regulate blood flow and tissue
oxygenation through allosterically controlled binding and delivery of nitric oxide (NO) and
oxygen in the vasculature. This precept and the experiments that test it have provoked both
ardent support and expanding dissent. An alternative view suggests that a physiologically
tightly regulated balance of NO scavenging by hemoglobin and NO production by
endothelial cells determines NO bioavailability.
oxygenation through allosterically controlled binding and delivery of nitric oxide (NO) and
oxygen in the vasculature. This precept and the experiments that test it have provoked both
ardent support and expanding dissent. An alternative view suggests that a physiologically
tightly regulated balance of NO scavenging by hemoglobin and NO production by
endothelial cells determines NO bioavailability.
S-nitroso-hemoglobin (SNOHb) has been proposed to regulate blood flow and tissue oxygenation through allosterically controlled binding and delivery of nitric oxide (NO) and oxygen in the vasculature. This precept and the experiments that test it have provoked both ardent support and expanding dissent. An alternative view suggests that a physiologically tightly regulated balance of NO scavenging by hemoglobin and NO production by endothelial cells determines NO bioavailability.
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