Maternal plasma angiogenic index-1 (placental growth factor/soluble vascular endothelial growth factor receptor-1) is a biomarker for the burden of placental lesions …
Background Placental lesions consistent with maternal vascular underperfusion (MVU) are
thought to be pathogenically linked to preeclampsia, small-for-gestational-age newborns,
fetal death, and spontaneous preterm labor and delivery; yet, these lesions cannot be
diagnosed antenatally. We previously reported that patients with such conditions and
lesions have an abnormal profile of the angiogenic placental growth factor (PlGF) and
antiangiogenic factors (eg, soluble vascular endothelial growth factor receptor [sVEGFR]-1) …
thought to be pathogenically linked to preeclampsia, small-for-gestational-age newborns,
fetal death, and spontaneous preterm labor and delivery; yet, these lesions cannot be
diagnosed antenatally. We previously reported that patients with such conditions and
lesions have an abnormal profile of the angiogenic placental growth factor (PlGF) and
antiangiogenic factors (eg, soluble vascular endothelial growth factor receptor [sVEGFR]-1) …