Background The maternal signs of preeclampsia, which include the new onset of high blood
pressure, can occur because of faulty placentation. We theorized that transcriptomic
analyses of trophoblast subpopulations in situ would lend new insights into the role of these
cells in preeclampsia pathogenesis. Objective Our goal was to enrich syncytiotrophoblasts,
invasive cytotrophoblasts, or endovascular cytotrophoblasts from the placentas of severe
preeclampsia cases. Total RNA was subjected to global transcriptional profiling to identify …