Influenza A viruses expressing intra-or intergroup chimeric hemagglutinins
ABSTRACT A panel of influenza A viruses expressing chimeric hemagglutinins (cHA) with
intragroup or intergroup head/stalk combinations was generated. Viruses were
characterized for growth kinetics and preservation of stalk epitopes. With a few notable
exceptions, cHA viruses behaved similarly to wild-type viruses and maintained stalk
epitopes, which indicated their potential as vaccine candidates to induce stalk-specific
antibodies.
intragroup or intergroup head/stalk combinations was generated. Viruses were
characterized for growth kinetics and preservation of stalk epitopes. With a few notable
exceptions, cHA viruses behaved similarly to wild-type viruses and maintained stalk
epitopes, which indicated their potential as vaccine candidates to induce stalk-specific
antibodies.
Abstract
A panel of influenza A viruses expressing chimeric hemagglutinins (cHA) with intragroup or intergroup head/stalk combinations was generated. Viruses were characterized for growth kinetics and preservation of stalk epitopes. With a few notable exceptions, cHA viruses behaved similarly to wild-type viruses and maintained stalk epitopes, which indicated their potential as vaccine candidates to induce stalk-specific antibodies.
American Society for Microbiology