A modified heterotopic swine hind limb transplant model for translational vascularized composite allotransplantation (VCA) research
Vascularized Composite Allotransplantation (VCA) such as hand and face transplants
represent a viable treatment option for complex musculoskeletal trauma and devastating
tissue loss. Despite favorable and highly encouraging early and intermediate functional
outcomes, rejection of the highly immunogenic skin component of a VCA and potential
adverse effects of chronic multi-drug immunosuppression continue to hamper widespread
clinical application of VCA. Therefore, research in this novel field needs to focus on …
represent a viable treatment option for complex musculoskeletal trauma and devastating
tissue loss. Despite favorable and highly encouraging early and intermediate functional
outcomes, rejection of the highly immunogenic skin component of a VCA and potential
adverse effects of chronic multi-drug immunosuppression continue to hamper widespread
clinical application of VCA. Therefore, research in this novel field needs to focus on …