[HTML][HTML] Prolonged niacin treatment leads to increased adipose tissue PUFA synthesis and anti-inflammatory lipid and oxylipin plasma profile [S]

MM Heemskerk, HK Dharuri, SAA van den Berg… - Journal of lipid …, 2014 - ASBMB
Prolonged niacin treatment elicits beneficial effects on the plasma lipid and lipoprotein
profile that is associated with a protective CVD risk profile. Acute niacin treatment inhibits
nonesterified fatty acid release from adipocytes and stimulates prostaglandin release from
skin Langerhans cells, but the acute effects diminish upon prolonged treatment, while the
beneficial effects remain. To gain insight in the prolonged effects of niacin on lipid
metabolism in adipocytes, we used a mouse model with a human-like lipoprotein …