Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

AJ Covarrubias, HI Aksoylar, J Yu, NW Snyder… - elife, 2016 - elifesciences.org
AJ Covarrubias, HI Aksoylar, J Yu, NW Snyder, AJ Worth, SS Iyer, J Wang, I Ben-Sahra
elife, 2016elifesciences.org
Macrophage activation/polarization to distinct functional states is critically supported by
metabolic shifts. How polarizing signals coordinate metabolic and functional
reprogramming, and the potential implications for control of macrophage activation, remains
poorly understood. Here we show that IL-4 signaling co-opts the Akt-mTORC1 pathway to
regulate Acly, a key enzyme in Ac-CoA synthesis, leading to increased histone acetylation
and M2 gene induction. Only a subset of M2 genes is controlled in this way, including those …
Macrophage activation/polarization to distinct functional states is critically supported by metabolic shifts. How polarizing signals coordinate metabolic and functional reprogramming, and the potential implications for control of macrophage activation, remains poorly understood. Here we show that IL-4 signaling co-opts the Akt-mTORC1 pathway to regulate Acly, a key enzyme in Ac-CoA synthesis, leading to increased histone acetylation and M2 gene induction. Only a subset of M2 genes is controlled in this way, including those regulating cellular proliferation and chemokine production. Moreover, metabolic signals impinge on the Akt-mTORC1 axis for such control of M2 activation. We propose that Akt-mTORC1 signaling calibrates metabolic state to energetically demanding aspects of M2 activation, which may define a new role for metabolism in supporting macrophage activation.
DOI: http://dx.doi.org/10.7554/eLife.11612.001
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