A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains

RGW Anderson, K Jacobson - Science, 2002 - science.org
RGW Anderson, K Jacobson
Science, 2002science.org
The surface membrane of cells is studded with morphologically distinct regions, or domains,
like microvilli, cell-cell junctions, and coated pits. Each of these domains is specialized for a
particular function, such as nutrient absorption, cell-cell communication, and endocytosis.
Lipid domains, which include caveolae and rafts, are one of the least understood membrane
domains. These domains are high in cholesterol and sphingolipids, have a light buoyant
density, and function in both endocytosis and cell signaling. A major mystery, however, is …
The surface membrane of cells is studded with morphologically distinct regions, or domains, like microvilli, cell-cell junctions, and coated pits. Each of these domains is specialized for a particular function, such as nutrient absorption, cell-cell communication, and endocytosis. Lipid domains, which include caveolae and rafts, are one of the least understood membrane domains. These domains are high in cholesterol and sphingolipids, have a light buoyant density, and function in both endocytosis and cell signaling. A major mystery, however, is how resident molecules are targeted to lipid domains. Here, we propose that the molecular address for proteins targeted to lipid domains is a lipid shell.
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