[HTML][HTML] A novel role for pyruvate kinase M2 as a corepressor for P53 during the DNA damage response in human tumor cells
L Xia, XR Wang, XL Wang, SH Liu, XW Ding… - Journal of Biological …, 2016 - ASBMB
The pyruvate kinase (PK) is a rate-limiting glycolytic enzyme catalyzing the
dephosphorylation of phosphoenolpyruvate to pyruvate, yielding one molecule of ATP. The
M2 isoform of PK (PKM2) is predominantly expressed in normal proliferating cells and
tumors, and both metabolic and non-metabolic activities for the enzyme in promoting tumor
cell proliferation have been identified. However, the exact roles of PKM2 in tumor initiation,
growth and maintenance are not yet fully understood. Using immunoprecipitation-coupled …
dephosphorylation of phosphoenolpyruvate to pyruvate, yielding one molecule of ATP. The
M2 isoform of PK (PKM2) is predominantly expressed in normal proliferating cells and
tumors, and both metabolic and non-metabolic activities for the enzyme in promoting tumor
cell proliferation have been identified. However, the exact roles of PKM2 in tumor initiation,
growth and maintenance are not yet fully understood. Using immunoprecipitation-coupled …