Development and proliferation of lymphocytes in mice deficient for both interleukins‐2 and‐4
European journal of immunology, 1994•Wiley Online Library
Abstract Interleukin (IL)‐2 and IL‐4 are considered as important regulators of growth and
differentiation of lymphocytes. We report that in mice made deficient for both IL‐2 and IL‐4
by gene targeting all major T cell subsets and B cells were normal, indicating that IL‐2 and
IL‐4 are not essential for development of the immune system. Paradoxically, proliferation of
T cells was increased in both IL‐2‐and IL‐4‐deficient homozygous mice.
differentiation of lymphocytes. We report that in mice made deficient for both IL‐2 and IL‐4
by gene targeting all major T cell subsets and B cells were normal, indicating that IL‐2 and
IL‐4 are not essential for development of the immune system. Paradoxically, proliferation of
T cells was increased in both IL‐2‐and IL‐4‐deficient homozygous mice.
Abstract
Interleukin (IL)‐2 and IL‐4 are considered as important regulators of growth and differentiation of lymphocytes. We report that in mice made deficient for both IL‐2 and IL‐4 by gene targeting all major T cell subsets and B cells were normal, indicating that IL‐2 and IL‐4 are not essential for development of the immune system. Paradoxically, proliferation of T cells was increased in both IL‐2‐ and IL‐4‐deficient homozygous mice.
Wiley Online Library