A physiological role for inducible FoxP3+ TReg cells: lessons from women with reproductive failure
L Arruvito, AI Sotelo, A Billordo, L Fainboim - Clinical Immunology, 2010 - Elsevier
We have previously shown a decreased frequency and function of Tregs in women suffering
from recurrent spontaneous abortions (RSA). In the current study, we first investigated the
expression of FOXP3 after T-cell activation. We observed that expression of FOXP3 in
activated PBMCs was already present above baseline before any cell division, indicating
that it was induced in cells that were previously negative for this transcription factor. Because
RSA women showed a more limited expansion of FOXP3-positive cells, we next assessed …
from recurrent spontaneous abortions (RSA). In the current study, we first investigated the
expression of FOXP3 after T-cell activation. We observed that expression of FOXP3 in
activated PBMCs was already present above baseline before any cell division, indicating
that it was induced in cells that were previously negative for this transcription factor. Because
RSA women showed a more limited expansion of FOXP3-positive cells, we next assessed …