Failure of physiologic transformation of the spiral arteries has been studied using placental
bed biopsies in several obstetrical syndromes. Contrary to what was originally believed, this
lesion is not restricted to preeclampsia and/or intrauterine growth restriction. A review of
published evidence indicates that failure of physiologic transformation can be observed in
women with spontaneous second trimester abortions, preterm labor with intact membranes,
preterm prelabor rupture of membranes and abruptio placentae. Therefore, disorders of …