Increased prevalence of T helper 17 (Th17) cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion patients
WJ Wang, CF Hao, GJ Yin, SH Bao, LH Qiu… - Journal of reproductive …, 2010 - Elsevier
T helper 17 (Th17) cells and regulatory T (Treg) cells are two distinct subsets of CD4+ T cells
which have opposite effects on inflammation, autoimmunity and immunological rejection of
foreign tissue. Treg cells have been shown to be important in maintaining materno-fetal
tolerance, but the role of Th17 cells in human pregnancy and pathological pregnancy,
especially in relation to unexplained recurrent spontaneous abortion (RSA), has not been
investigated. In this study, we showed that the proportion of Th17 cells in the peripheral …
which have opposite effects on inflammation, autoimmunity and immunological rejection of
foreign tissue. Treg cells have been shown to be important in maintaining materno-fetal
tolerance, but the role of Th17 cells in human pregnancy and pathological pregnancy,
especially in relation to unexplained recurrent spontaneous abortion (RSA), has not been
investigated. In this study, we showed that the proportion of Th17 cells in the peripheral …