[HTML][HTML] New strategies for cancer immunotherapy: targeting regulatory T cells
F Finotello, Z Trajanoski - Genome medicine, 2017 - Springer
Genome medicine, 2017•Springer
The immunosuppressive action of regulatory T (T reg) cells is one mechanism attributed to
the limited success of cancer immunotherapies with checkpoint blockers. Two recent studies
report distinct transcriptional profiles of tumor-infiltrating T reg cells and expression of
specific molecules, suggesting novel strategies to overcome resistance to cancer
immunotherapy.
the limited success of cancer immunotherapies with checkpoint blockers. Two recent studies
report distinct transcriptional profiles of tumor-infiltrating T reg cells and expression of
specific molecules, suggesting novel strategies to overcome resistance to cancer
immunotherapy.
Abstract
The immunosuppressive action of regulatory T (Treg) cells is one mechanism attributed to the limited success of cancer immunotherapies with checkpoint blockers. Two recent studies report distinct transcriptional profiles of tumor-infiltrating Treg cells and expression of specific molecules, suggesting novel strategies to overcome resistance to cancer immunotherapy.
Springer