Effect of progestins on immunity: medroxyprogesterone but not norethisterone or levonorgestrel suppresses the function of T cells and pDCs
RPH Huijbregts, KG Michel, Z Hel - Contraception, 2014 - Elsevier
Objectives The potential effect of hormonal contraception on HIV-1 acquisition and
transmission represents an important public health issue. Several observational studies
have suggested an association between the use of hormonal contraception, in particular
injectable depot medroxyprogesterone acetate (DMPA), and an increased risk of HIV-1
acquisition and transmission. We and others have previously demonstrated that DMPA acts
as a potent inhibitor of innate and adaptive immune mechanisms. The study presented here …
transmission represents an important public health issue. Several observational studies
have suggested an association between the use of hormonal contraception, in particular
injectable depot medroxyprogesterone acetate (DMPA), and an increased risk of HIV-1
acquisition and transmission. We and others have previously demonstrated that DMPA acts
as a potent inhibitor of innate and adaptive immune mechanisms. The study presented here …