Progesterone receptor-estrogen receptor crosstalk: a novel insight
C Thomas, JÅ Gustafsson - Trends in Endocrinology & Metabolism, 2015 - cell.com
Trends in Endocrinology & Metabolism, 2015•cell.com
Copy number loss of the PGR gene and decreased expression of progesterone receptor
(PR) may account for worse clinical outcomes in some individuals with estrogen receptor α
(ERα)-positive breast cancer. A recent report shows that PR activation inhibits estrogen-
driven breast tumor growth by altering ERα chromatin binding and transcriptional activity.
(PR) may account for worse clinical outcomes in some individuals with estrogen receptor α
(ERα)-positive breast cancer. A recent report shows that PR activation inhibits estrogen-
driven breast tumor growth by altering ERα chromatin binding and transcriptional activity.
Copy number loss of the PGR gene and decreased expression of progesterone receptor (PR) may account for worse clinical outcomes in some individuals with estrogen receptor α (ERα)-positive breast cancer. A recent report shows that PR activation inhibits estrogen-driven breast tumor growth by altering ERα chromatin binding and transcriptional activity.
cell.com