The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit
J Karn - Current opinion in HIV and AIDS, 2011 - journals.lww.com
Current opinion in HIV and AIDS, 2011•journals.lww.com
Strategies to purge the latent proviral pool require nontoxic activator molecules. The multiple
restrictions imposed on latent proviruses that need to be overcome suggest that proviral
reactivation will not be achieved when only a single reactivation step is targeted but will
require both removal of epigenetic blocks and the activation of P-TEFb. Alternatively, new
inhibitors that block proviral reactivation could be developed.
restrictions imposed on latent proviruses that need to be overcome suggest that proviral
reactivation will not be achieved when only a single reactivation step is targeted but will
require both removal of epigenetic blocks and the activation of P-TEFb. Alternatively, new
inhibitors that block proviral reactivation could be developed.
Summary
Strategies to purge the latent proviral pool require nontoxic activator molecules. The multiple restrictions imposed on latent proviruses that need to be overcome suggest that proviral reactivation will not be achieved when only a single reactivation step is targeted but will require both removal of epigenetic blocks and the activation of P-TEFb. Alternatively, new inhibitors that block proviral reactivation could be developed.
Lippincott Williams & Wilkins