[HTML][HTML] Excess type I interferon signaling in the mouse seminiferous tubules leads to germ cell loss and sterility
AP Satie, S Mazaud-Guittot, I Seif, D Mahé, Z He… - Journal of Biological …, 2011 - ASBMB
Type I (α and β) interferons (IFNs) elicit antiproliferative and antiviral activities via the surface
receptor IFNAR. Serendipitous observations in transgenic mice in 1988 strongly suggested
that IFNα/β overexpression in the testis disrupts spermatogenesis. Here, we compare a new
mouse strain transgenic for IFNβ (Tg10) and a sister strain lacking the IFNAR1 subunit of
IFNAR (Tg10-Ifnar1−/−), both strains expressing the transgene in the testis. The main source
of IFNβ RNA was the spermatid population. Importantly, the Tg10 mice, but not the double …
receptor IFNAR. Serendipitous observations in transgenic mice in 1988 strongly suggested
that IFNα/β overexpression in the testis disrupts spermatogenesis. Here, we compare a new
mouse strain transgenic for IFNβ (Tg10) and a sister strain lacking the IFNAR1 subunit of
IFNAR (Tg10-Ifnar1−/−), both strains expressing the transgene in the testis. The main source
of IFNβ RNA was the spermatid population. Importantly, the Tg10 mice, but not the double …