Polyamines and cancer: old molecules, new understanding
EW Gerner, FL Meyskens Jr - Nature Reviews Cancer, 2004 - nature.com
EW Gerner, FL Meyskens Jr
Nature Reviews Cancer, 2004•nature.comThe amino-acid-derived polyamines have long been associated with cell growth and cancer,
and specific oncogenes and tumour-suppressor genes regulate polyamine metabolism.
Inhibition of polyamine synthesis has proven to be generally ineffective as an anticancer
strategy in clinical trials, but it is a potent cancer chemoprevention strategy in preclinical
studies. Clinical trials, with well-defined goals, are now underway to evaluate the
chemopreventive efficacy of inhibitors of polyamine synthesis in a range of tissues.
and specific oncogenes and tumour-suppressor genes regulate polyamine metabolism.
Inhibition of polyamine synthesis has proven to be generally ineffective as an anticancer
strategy in clinical trials, but it is a potent cancer chemoprevention strategy in preclinical
studies. Clinical trials, with well-defined goals, are now underway to evaluate the
chemopreventive efficacy of inhibitors of polyamine synthesis in a range of tissues.
Abstract
The amino-acid-derived polyamines have long been associated with cell growth and cancer, and specific oncogenes and tumour-suppressor genes regulate polyamine metabolism. Inhibition of polyamine synthesis has proven to be generally ineffective as an anticancer strategy in clinical trials, but it is a potent cancer chemoprevention strategy in preclinical studies. Clinical trials, with well-defined goals, are now underway to evaluate the chemopreventive efficacy of inhibitors of polyamine synthesis in a range of tissues.
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