[HTML][HTML] Identification of the aryl hydrocarbon receptor target gene TiPARP as a mediator of suppression of hepatic gluconeogenesis by 2, 3, 7, 8-tetrachlorodibenzo-p …
The environmental toxin TCDD (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin, dioxin) produces
diverse toxic effects including a lethal wasting syndrome whose hallmark is suppressed
hepatic gluconeogenesis. All TCDD toxicities require activation of the aryl hydrocarbon
receptor (AHR), a ligand-activated transcription factor. Whereas the mechanism for AHR
induction of target genes is well understood, it is not known how AHR activation produces
any TCDD toxicity. This report identifies for the first time an AHR target gene, TiPARP (TCDD …
diverse toxic effects including a lethal wasting syndrome whose hallmark is suppressed
hepatic gluconeogenesis. All TCDD toxicities require activation of the aryl hydrocarbon
receptor (AHR), a ligand-activated transcription factor. Whereas the mechanism for AHR
induction of target genes is well understood, it is not known how AHR activation produces
any TCDD toxicity. This report identifies for the first time an AHR target gene, TiPARP (TCDD …