[HTML][HTML] Dioxin receptor expression inhibits basal and transforming growth factor β-induced epithelial-to-mesenchymal transition
EM Rico-Leo, A Alvarez-Barrientos… - Journal of Biological …, 2013 - ASBMB
Recent studies have emphasized the role of the dioxin receptor (AhR) in maintaining cell
morphology, adhesion, and migration. These novel AhR functions depend on the cell
phenotype, and although AhR expression maintains mesenchymal fibroblasts migration, it
inhibits keratinocytes motility. These observations prompted us to investigate whether AhR
modulates the epithelial-to-mesenchymal transition (EMT). For this, we have used primary
AhR+/+ and AhR−/− keratinocytes and NMuMG cells engineered to knock down AhR levels …
morphology, adhesion, and migration. These novel AhR functions depend on the cell
phenotype, and although AhR expression maintains mesenchymal fibroblasts migration, it
inhibits keratinocytes motility. These observations prompted us to investigate whether AhR
modulates the epithelial-to-mesenchymal transition (EMT). For this, we have used primary
AhR+/+ and AhR−/− keratinocytes and NMuMG cells engineered to knock down AhR levels …