[HTML][HTML] T-cell immunity to human alphaherpesviruses
WJD Ouwendijk, KJ Laing, GMGM Verjans… - Current opinion in …, 2013 - Elsevier
Highlights•HSV T-cell immunity relies on multiple DC subsets and CD4/CD8 T-cell
cooperation.•Diverse CD4/CD8 responses to HSV-1 are accessible with genome-spanning
tools.•HSV-specific T-cells localize to mucosal epithelia during recurrent infections.•HSV-1-
specific T-cells localize to ganglia during chronic latent infection.•VZV reactivation induces
systemic and ganglionic T-cell responses.Human alphaherpesviruses (αHHV)—herpes
simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV)—infect mucosal …
cooperation.•Diverse CD4/CD8 responses to HSV-1 are accessible with genome-spanning
tools.•HSV-specific T-cells localize to mucosal epithelia during recurrent infections.•HSV-1-
specific T-cells localize to ganglia during chronic latent infection.•VZV reactivation induces
systemic and ganglionic T-cell responses.Human alphaherpesviruses (αHHV)—herpes
simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV)—infect mucosal …