Declining effectiveness of herpes zoster vaccine in adults aged≥ 60 years
HF Tseng, R Harpaz, Y Luo, CM Hales… - The Journal of …, 2016 - academic.oup.com
HF Tseng, R Harpaz, Y Luo, CM Hales, LS Sy, SY Tartof, S Bialek, RC Hechter, SJ Jacobsen
The Journal of infectious diseases, 2016•academic.oup.comUnderstanding long-term effectiveness of herpes zoster (HZ) vaccine is critical for
determining vaccine policy. 176 078 members of Kaiser Permanente≥ 60 years vaccinated
with HZ vaccine and three matched unvaccinated members were included. Hazard ratios
and 95% confidence intervals (CIs) associated with vaccination at each year following
vaccination were estimated by Cox regression model. The effectiveness of HZ vaccine
decreased from 68.7%(95% CI, 66.3%–70.9%) in the first year to 4.2%(95% CI,− 24.0% to …
determining vaccine policy. 176 078 members of Kaiser Permanente≥ 60 years vaccinated
with HZ vaccine and three matched unvaccinated members were included. Hazard ratios
and 95% confidence intervals (CIs) associated with vaccination at each year following
vaccination were estimated by Cox regression model. The effectiveness of HZ vaccine
decreased from 68.7%(95% CI, 66.3%–70.9%) in the first year to 4.2%(95% CI,− 24.0% to …
Abstract
Understanding long-term effectiveness of herpes zoster (HZ) vaccine is critical for determining vaccine policy. 176 078 members of Kaiser Permanente ≥60 years vaccinated with HZ vaccine and three matched unvaccinated members were included. Hazard ratios and 95% confidence intervals (CIs) associated with vaccination at each year following vaccination were estimated by Cox regression model. The effectiveness of HZ vaccine decreased from 68.7% (95% CI, 66.3%–70.9%) in the first year to 4.2% (95% CI, −24.0% to 25.9%) in the eighth year. This rapid decline in effectiveness of HZ vaccine suggests that a revaccination strategy may be needed, if feasible.
Oxford University Press