[HTML][HTML] NFκB-dependent control of BACE1 promoter transactivation by Aβ42
V Buggia-Prevot, J Sevalle, S Rossner… - Journal of Biological …, 2008 - ASBMB
β-Amyloid (Aβ) peptides that accumulate in Alzheimer disease are generated from the β-
amyloid precursor protein (βAPP) by cleavages by β-secretase BACE1 and by presenilin-
dependent γ-secretase activities. Very few data document a putative cross-talk between
these proteases and the regulatory mechanisms underlying such interaction. We show that
presenilin deficiency lowers BACE1 maturation and affects both BACE1 activity and
promoter transactivation. The specific γ-secretase inhibitor DFK167 triggers the decrease of …
amyloid precursor protein (βAPP) by cleavages by β-secretase BACE1 and by presenilin-
dependent γ-secretase activities. Very few data document a putative cross-talk between
these proteases and the regulatory mechanisms underlying such interaction. We show that
presenilin deficiency lowers BACE1 maturation and affects both BACE1 activity and
promoter transactivation. The specific γ-secretase inhibitor DFK167 triggers the decrease of …