Heterogeneous genetic alterations in sporadic nephrotic syndrome associate with resistance to immunosuppression
S Giglio, A Provenzano, B Mazzinghi… - Journal of the …, 2015 - journals.lww.com
In children, sporadic nephrotic syndrome can be related to a genetic cause, but to what
extent genetic alterations associate with resistance to immunosuppression is unknown. In
this study, we designed a custom array for next-generation sequencing analysis of 19 target
genes, reported as possible causes of nephrotic syndrome, in a cohort of 31 children
affected by sporadic steroid-resistant nephrotic syndrome and 38 patients who exhibited a
similar but steroid-sensitive clinical phenotype. Patients who exhibited extrarenal symptoms …
extent genetic alterations associate with resistance to immunosuppression is unknown. In
this study, we designed a custom array for next-generation sequencing analysis of 19 target
genes, reported as possible causes of nephrotic syndrome, in a cohort of 31 children
affected by sporadic steroid-resistant nephrotic syndrome and 38 patients who exhibited a
similar but steroid-sensitive clinical phenotype. Patients who exhibited extrarenal symptoms …