[HTML][HTML] Loss of zygotic NUP107 protein causes missing of pharyngeal skeleton and other tissue defects with impaired nuclear pore function in zebrafish embryos
X Zheng, S Yang, Y Han, X Zhao, L Zhao, T Tian… - Journal of Biological …, 2012 - ASBMB
The Nup107–160 multiprotein subcomplex is essential for the assembly of nuclear pore
complexes. The developmental functions of individual constituents of this subcomplex in
vertebrates remain elusive. In particular, it is unknown whether Nup107 plays an important
role in development of vertebrate embryos. Zebrafish nup107 is maternally expressed and
its zygotic expression becomes prominent in the head region and the intestine from 24 h
postfertilization (hpf) onward. In this study, we generate a zebrafish mutant line, nup107 …
complexes. The developmental functions of individual constituents of this subcomplex in
vertebrates remain elusive. In particular, it is unknown whether Nup107 plays an important
role in development of vertebrate embryos. Zebrafish nup107 is maternally expressed and
its zygotic expression becomes prominent in the head region and the intestine from 24 h
postfertilization (hpf) onward. In this study, we generate a zebrafish mutant line, nup107 …