Regression of glomerulosclerosis with high-dose angiotensin inhibition is linked to decreased plasminogen activator inhibitor-1
LJ Ma, S Nakamura, JC Aldigier… - Journal of the …, 2005 - journals.lww.com
The potential and possible mechanisms for regression of existing glomerulosclerosis by
angiotensin II type 1 receptor antagonist (AT1RA) and/or angiotensin I converting enzyme
inhibitor (ACEI) were investigated. Adult male Sprague Dawley rats underwent 5/6
nephrectomy (Nx). Glomerulosclerosis was assessed by renal biopsy 8 wk later, and rats
were divided into groups with equal biopsy sclerosis and treated for the next 4 wk until they
were killed at 12 wk as follows: Control with no further treatment (CONT), high-dose AT1RA …
angiotensin II type 1 receptor antagonist (AT1RA) and/or angiotensin I converting enzyme
inhibitor (ACEI) were investigated. Adult male Sprague Dawley rats underwent 5/6
nephrectomy (Nx). Glomerulosclerosis was assessed by renal biopsy 8 wk later, and rats
were divided into groups with equal biopsy sclerosis and treated for the next 4 wk until they
were killed at 12 wk as follows: Control with no further treatment (CONT), high-dose AT1RA …