[HTML][HTML] Expression profiling of small intestinal neuroendocrine tumors identifies subgroups with clinical relevance, prognostic markers and therapeutic targets
E Andersson, Y Arvidsson, C Swärd, T Hofving… - Modern Pathology, 2016 - Elsevier
We wanted to define the transcriptome of small intestinal neuroendocrine tumors in order to
identify clinically relevant subgroups of tumors, prognostic markers and novel targets for
treatment. Genome-wide expression profiling was conducted on tumor biopsies from 33
patients with well-differentiated neuroendocrine tumors of the distal ileum and metastatic
disease at the time of diagnosis. Unsupervised hierarchical clustering analysis identified
three groups of tumors. The largest group, comprising half of the tumors, was characterized …
identify clinically relevant subgroups of tumors, prognostic markers and novel targets for
treatment. Genome-wide expression profiling was conducted on tumor biopsies from 33
patients with well-differentiated neuroendocrine tumors of the distal ileum and metastatic
disease at the time of diagnosis. Unsupervised hierarchical clustering analysis identified
three groups of tumors. The largest group, comprising half of the tumors, was characterized …